MicroRNA-200c Represses IL-6, IL-8, and CCL-5 Expression and Enhances Osteogenic Differentiation.
Hong L, Sharp T, Khorsand B, Fischer C, Eliason S, Salem A, Akkouch A, Brogden K, Amendt BA.
PLoS One. 2016 Aug 16;11(8):e0160915. doi: 10.1371/journal.pone.0160915. eCollection 2016.

A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent.
Cao H, Yu W, Li X, Wang J, Gao S, Holton NE, Eliason S, Sharp T, Amendt BA.
Gene Ther. 2016 Jul;23(7):634. doi: 10.1038/gt.2016.44. No abstract available.
PMID: 27383391.

pySAPC, a python package for sparse affinity propagation clustering: Application to odontogenesis whole genome time series gene-expression data.
Cao H, Amendt BA.
Biochim Biophys Acta. 2016 Jun 8. pii: S0304-4165(16)30213-6. doi: 10.1016/j.bbagen.2016.06.008. [Epub ahead of print]
PMID: 27288587

Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury.
Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA, Martin JF.
Nature. 2016 May 25;534(7605):119-23. doi: 10.1038/nature17959.
PMID: 27251288


Bioactive nanofibers enable the identification of thrombospondin 2 as a key player in enamel regeneration.  Huang Z, Newcomb CJ, Lei Y, Zhou Y, Bornstein P, Amendt BA, Stupp SI, Snead ML.  Biomaterials. 2015 May 19;61:216-228. j.biomaterials.2015.05.035.

 Candidate Gene Analyses of Skeletal Variation in Malocclusion.   da Fontoura CS, Miller SF, Wehby GL, Amendt BA, Holton NE, Southard TE, Allareddy V, Moreno Uribe LM.  J Dent Res. 2015 Apr 24.


TBX1 protein interactions and microRNA-96-5p regulation controls cell proliferation during craniofacial and dental development: implications for 22q11.2 deletion syndrome.  Gao S, Moreno M, Eliason S, Cao H, Li X, Yu W, Bidlack FB, Margolis HC, Baldini A, Amendt BAHum Mol Genet. 2015 Apr 15;24(8):2330-48. doi: 10.1093/hmg/ddu750. Epub 2015 Jan 2

A Pituitary Homeobox 2 (Pitx2):microRNA-200a-3p:Beta-catenin Pathway Converts Mesenchyme Cells to Amelogenin-Expressing Dental Epithelial Cells.  Sharp T, Wang J, Li X, Cao H, Gao S, Moreno M, Amendt BA.   J Biol Chem. 2014 Aug 13.

MicroRNA-26b Represses Colon Cancer Cell Proliferation by Inhibiting Lymphoid Enhancer Factor 1 Expression.  Zhang Z, Kim K, Li X, Moreno M, Sharp T, Goodheart MJ, Safe S, Dupuy AJ, Amendt BA.  Mol Cancer Ther. 2014 Jul;13(7):1942-51. Epub 2014 Apr 30.


Understanding the role of tbx1 as a candidate gene for 22q11.2 deletion syndrome.
Gao S, Li X, Amendt BA.
Curr Allergy Asthma Rep. 2013 Dec;13(6):613-21. doi: 10.1007/s11882-013-0384-6.

A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome.
Li X, Venugopalan SR, Cao H, Pinho FO, Paine ML, Snead ML, Semina EV, Amendt BA.
Hum Mol Genet. 2014 Jan 1;23(1):194-208. doi: 10.1093/hmg/ddt411. Epub 2013 Aug 23.

The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.
Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA.
Development. 2013 Aug;140(16):3348-59. doi: 10.1242/dev.089193. Epub 2013 Jul 17.

Differentiation of human dental stem cells reveals a role for microRNA-218.
Gay I, Cavender A, Peto D, Sun Z, Speer A, Cao H, Amendt BA.
J Periodontal Res. 2013 May 13. doi: 10.1111/jre.12086. [Epub ahead of print]

Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.
Wang J, Sun Z, Zhang Z, Saadi I, Wang J, Li X, Gao S, Engle JJ, Kuburas A, Fu X, Yu W, Klein WH, Russo AF, Amendt BA.
J Biol Chem. 2013 May 3;288(18):12580-95. doi: 10.1074/jbc.M112.374561. Epub 2013 Mar 20.

Dact2 represses PITX2 transcriptional activation and cell proliferation through Wnt/beta-catenin signaling during odontogenesis.
Li X, Florez S, Wang J, Cao H, Amendt BA.
PLoS One. 2013;8(1):e54868. doi: 10.1371/journal.pone.0054868. Epub 2013 Jan 22.

The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis.
Zhang Z, Gutierrez D, Li X, Bidlack F, Cao H, Wang J, Andrade K, Margolis HC, Amendt BA.
J Biol Chem. 2013 Jan 25;288(4):2485-500. doi: 10.1074/jbc.M112.402933. Epub 2012 Dec 10.


An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud.
Jumlongras D, Lachke SA, O'Connell DJ, Aboukhalil A, Li X, Choe SE, Ho JW, Turbe-Doan A, Robertson EA, Olsen BR, Bulyk ML, Amendt BA, Maas RL.
PLoS One. 2012;7(6):e38568. doi: 10.1371/journal.pone.0038568. Epub 2012 Jun 12.

Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.
Zhou GD, Zhu H, Phillips TD, Wang J, Wang SZ, Wang F, Amendt BA, Couroucli XI, Donnelly KC, Moorthy B.
PLoS One. 2011;6(10):e26589. doi: 10.1371/journal.pone.0026589. Epub 2011 Oct 31.

Fuz regulates craniofacial development through tissue specific responses to signaling factors.
Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA.
PLoS One. 2011;6(9):e24608. doi: 10.1371/journal.pone.0024608. Epub 2011 Sep 14.

Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression.
Venugopalan SR, Li X, Amen MA, Florez S, Gutierrez D, Cao H, Wang J, Amendt BA.
J Biol Chem. 2011 Jun 17;286(24):21372-83. doi: 10.1074/jbc.M111.252031. Epub 2011 Apr 19.


Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21.
Cao H, Florez S, Amen M, Huynh T, Skobe Z, Baldini A, Amendt BA.
Dev Biol. 2010 Nov 15;347(2):289-300. doi: 10.1016/j.ydbio.2010.08.031. Epub 2010 Sep 15.

MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression.
Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA.
J Biol Chem. 2010 Nov 5;285(45):34718-28. doi: 10.1074/jbc.M110.126441. Epub 2010 Aug 31.

MicroRNAs play a critical role in tooth development.
Cao H, Wang J, Li X, Florez S, Huang Z, Venugopalan SR, Elangovan S, Skobe Z, Margolis HC, Martin JF, Amendt BA.
J Dent Res. 2010 Aug;89(8):779-84. doi: 10.1177/0022034510369304. Epub 2010 May 26.

Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway.
Taniguchi N, Caramés B, Kawakami Y, Amendt BA, Komiya S, Lotz M.
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16817-22. doi: 10.1073/pnas.0904414106. Epub 2009 Sep 10.

The Pitx2c N-terminal domain is a critical interaction domain required for asymmetric morphogenesis.
Simard A, Di Giorgio L, Amen M, Westwood A, Amendt BA, Ryan AK.
Dev Dyn. 2009 Oct;238(10):2459-70. doi: 10.1002/dvdy.22062.

Bone marrow cells produce a novel TSHbeta splice variant that is upregulated in the thyroid following systemic virus infection.
Vincent BH, Montufar-Solis D, Teng BB, Amendt BA, Schaefer J, Klein JR.
Genes Immun. 2009 Jan;10(1):18-26. doi: 10.1038/gene.2008.69. Epub 2008 Aug 28.

2008 and before…

Novel expression and transcriptional regulation of FoxJ1 during oro-facial morphogenesis.
Venugopalan SR, Amen MA, Wang J, Wong L, Cavender AC, D'Souza RN, Akerlund M, Brody SL, Hjalt TA, Amendt BA.
Hum Mol Genet. 2008 Dec 1;17(23):3643-54. doi: 10.1093/hmg/ddn258. Epub 2008 Aug 22.

Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation.
Shang Y, Yoshida T, Amendt BA, Martin JF, Owens GK.
J Cell Biol. 2008 May 5;181(3):461-73. doi: 10.1083/jcb.200711145.

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.
Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6. doi: 10.1073/pnas.0708257105. Epub 2008 Apr 18.

Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling.
Amen M, Espinoza HM, Cox C, Liang X, Wang J, Link TM, Brennan RG, Martin JF, Amendt BA. Nucleic Acids Res. 2008 Feb;36(2):462-76. Epub 2007 Nov 27.

PITX2 and beta-catenin interactions regulate Lef-1 isoform expression.
Amen M, Liu X, Vadlamudi U, Elizondo G, Diamond E, Engelhardt JF, Amendt BA.
Mol Cell Biol. 2007 Nov;27(21):7560-73. Epub 2007 Sep 4.

Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development.
Ai D, Wang J, Amen M, Lu MF, Amendt BA, Martin JF.
Mol Cell Biol. 2007 Aug;27(16):5765-75. Epub 2007 Jun 11.

Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2.
Diamond E, Amen M, Hu Q, Espinoza HM, Amendt BA.
Nucleic Acids Res. 2006;34(20):5951-65. Epub 2006 Oct 26.

Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein.
Espinoza HM, Ganga M, Vadlamudi U, Martin DM, Brooks BP, Semina EV, Murray JC, Amendt BA. Biochemistry. 2005 Mar 15;44(10):3942-54.

PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter.
Vadlamudi U, Espinoza HM, Ganga M, Martin DM, Liu X, Engelhardt JF, Amendt BA.
J Cell Sci. 2005 Mar 15;118(Pt 6):1129-37. Epub 2005 Feb 22.

Analysis of two translocation breakpoints and identification of a negative regulatory element in patients with Rieger's syndrome.
Trembath DG, Semina EV, Jones DH, Patil SR, Qian Q, Amendt BA, Russo AF, Murray JC.
Birth Defects Res A Clin Mol Teratol. 2004 Feb;70(2):82-91.

PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5.
Ganga M, Espinoza HM, Cox CJ, Morton L, Hjalt TA, Lee Y, Amendt BA.
J Biol Chem. 2003 Jun 20;278(25):22437-45. Epub 2003 Apr 11.

Homeobox protein, Hmx3, in postnatally developing rat submandibular glands.
Shaw PA, Zhang X, Russo AF, Amendt BA, Henderson S, Williams V.
J Histochem Cytochem. 2003 Mar;51(3):385-96.

Differential regulation of gene expression by PITX2 isoforms.
Cox CJ, Espinoza HM, McWilliams B, Chappell K, Morton L, Hjalt TA, Semina EV, Amendt BA.
J Biol Chem. 2002 Jul 12;277(28):25001-10. Epub 2002 Apr 10.

A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome.
Espinoza HM, Cox CJ, Semina EV, Amendt BA.
Hum Mol Genet. 2002 Apr 1;11(7):743-53.

Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development.
Green PD, Hjalt TA, Kirk DE, Sutherland LB, Thomas BL, Sharpe PT, Snead ML, Murray JC, Russo AF, Amendt BA. Gene Expr. 2001;9(6):265-81.

Identification of a dominant negative homeodomain mutation in Rieger syndrome.
Saadi I, Semina EV, Amendt BA, Harris DJ, Murphy KP, Murray JC, Russo AF.
J Biol Chem. 2001 Jun 22;276(25):23034-41. Epub 2001 Apr 11.

PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome.
Hjalt TA, Amendt BA, Murray JC.
J Cell Biol. 2001 Feb 5;152(3):545-52.

Rieger syndrome: a clinical, molecular, and biochemical analysis.
Amendt BA, Semina EV, Alward WL.
Cell Mol Life Sci. 2000 Oct;57(11):1652-66. Review.

The Pitx2 protein in mouse development.
Hjalt TA, Semina EV, Amendt BA, Murray JC.
Dev Dyn. 2000 May;218(1):195-200.

Multifunctional role of the Pitx2 homeodomain protein C-terminal tail.
Amendt BA, Sutherland LB, Russo AF.
Mol Cell Biol. 1999 Oct;19(10):7001-10.

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site.
Amendt BA, Sutherland LB, Russo AF.
J Biol Chem. 1999 Apr 23;274(17):11635-42.

The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities.
Amendt BA, Sutherland LB, Semina EV, Russo AF.
J Biol Chem. 1998 Aug 7;273(32):20066-72.

Splicing efficiency of human immunodeficiency virus type 1 tat RNA is determined by both a suboptimal 3' splice site and a 10 nucleotide exon splicing silencer element located within tat exon 2. 
Si Z, Amendt BA, Stoltzfus CM.
Nucleic Acids Res. 1997 Feb 15;25(4):861-7.

Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factors.
Amendt BA, Si ZH, Stoltzfus CM.
Mol Cell Biol. 1995 Nov;15(11):6480. No abstract available. 

Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factors.
Amendt BA, Si ZH, Stoltzfus CM.
Mol Cell Biol. 1995 Aug;15(8):4606-15. Erratum in: Mol Cell Biol. 1995 Nov;15(11):6480. 

Inhibition of RNA splicing at the Rous sarcoma virus src 3' splice site is mediated by an interaction between a negative cis element and a chicken embryo fibroblast nuclear factor.
Amendt BA, Simpson SB, Stoltzfus CM.
J Virol. 1995 Aug;69(8):5068-76.

The hinge deletion allelic variant of porcine IgA results from a mutation at the splice acceptor site in the first C alpha intron.
Brown WR, Kacskovics I, Amendt BA, Blackmore NB, Rothschild M, Shinde R, Butler JE.
J Immunol. 1995 Apr 15;154(8):3836-42.

Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1.
Amendt BA, Hesslein D, Chang LJ, Stoltzfus CM.
Mol Cell Biol. 1994 Jun;14(6):3960-70.

Short-chain acyl-coenzyme A dehydrogenase activity, antigen, and biosynthesis are absent in the BALB/cByJ mouse.
Amendt BA, Freneaux E, Reece C, Wood PA, Rhead WJ.
Pediatr Res. 1992 Jun;31(6):552-6.

A murine model for short-chain acyl-CoA dehydrogenase deficiency.
Wood PA, Amendt BA, Rhead WJ, Armstrong D, Millington DS, Inoue F.
Prog Clin Biol Res. 1990;321:427-34. No abstract available. 

Short-chain acyl-coenzyme A dehydrogenase deficiency in mice.
Wood PA, Amendt BA, Rhead WJ, Millington DS, Inoue F, Armstrong D.
Pediatr Res. 1989 Jan;25(1):38-43.

Long-chain acyl-coenzyme A dehydrogenase deficiency: biochemical studies in fibroblasts from three patients.
Amendt BA, Moon A, Teel L, Rhead WJ.
Pediatr Res. 1988 Jun;23(6):603-5.

Short-chain acyl-coenzyme A dehydrogenase deficiency. Clinical and biochemical studies in two patients.
Amendt BA, Greene C, Sweetman L, Cloherty J, Shih V, Moon A, Teel L, Rhead WJ.
J Clin Invest. 1987 May;79(5):1303-9.

The multiple acyl-coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. Mitochondrial fatty acid oxidation, acyl-coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts.
Amendt BA, Rhead WJ.
J Clin Invest. 1986 Jul;78(1):205-13.

Catalytic defect of medium-chain acyl-coenzyme A dehydrogenase deficiency. Lack of both cofactor responsiveness and biochemical heterogeneity in eight patients.
Amendt BA, Rhead WJ.
J Clin Invest. 1985 Sep;76(3):963-9.

Electron-transferring flavoprotein deficiency in the multiple acyl-CoA dehydrogenation disorders, glutaric aciduria type II and ethylmalonic--adipic aciduria.
Rhead WJ, Amendt BA.
J Inherit Metab Dis. 1984;7 Suppl 2:99-100. No abstract available. 

Dicarboxylic aciduria: deficient [1-14C]octanoate oxidation and medium-chain acyl-CoA dehydrogenase in fibroblasts.
Rhead WJ, Amendt BA, Fritchman KS, Felts SJ.
Science. 1983 Jul 1;221(4605):73-5.